Kindlin-3 recruitment to the plasma membrane precedes high-affinity β(2)-integrin and neutrophil arrest from rolling

Integrin-mediated neutrophil adhesion starts by arrest from rolling. Activation of integrins involves conformational changes from an inactive, bent conformation to an extended conformation (E(+)) with high affinity for ligand binding (H(+)). The cytoplasmic protein kindlin-3 is necessary for leukocy...

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Vydáno v:Blood
Hlavní autoři: Wen, Lai, Marki, Alex, Roy, Payel, McArdle, Sara, Sun, Hao, Fan, Zhichao, Gingras, Alexandre R., Ginsberg, Mark H., Ley, Klaus
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2021
Témata:
Immunobiology and Immunotherapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808012/
https://ncbi.nlm.nih.gov/pubmed/32777822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003446
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