Neutrophil recruitment limited by high-affinity bent β(2) integrin binding ligand in cis

Neutrophils are essential for innate immunity and inflammation and many neutrophil functions are β(2) integrin-dependent. Integrins can extend (E(+)) and acquire a high-affinity conformation with an ‘open' headpiece (H(+)). The canonical switchblade model of integrin activation proposes that th...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Fan, Zhichao, McArdle, Sara, Marki, Alex, Mikulski, Zbigniew, Gutierrez, Edgar, Engelhardt, Britta, Deutsch, Urban, Ginsberg, Mark, Groisman, Alex, Ley, Klaus
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013657/
https://ncbi.nlm.nih.gov/pubmed/27578049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12658
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