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B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells
The long noncoding RNA (lncRNA) XIST establishes X chromosome inactivation (XCI) in female cells in early development and thereafter is thought to be largely dispensable. Here we show XIST is continually required in adult human B cells to silence a subset of X-linked immune genes such as TLR7 . XIST...
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| Publicado no: | bioRxiv |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7805439/ https://ncbi.nlm.nih.gov/pubmed/33442682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.03.425167 |
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