Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity

Lectins, carbohydrate-binding proteins, have been regarded as potential antiviral agents, as some can bind glycans on viral surface glycoproteins and inactivate their functions. However, clinical development of lectins has been stalled by the mitogenicity of many of these proteins, which is the abil...

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Udgivet i:Sci Rep
Main Authors: Covés-Datson, Evelyn M., King, Steven R., Legendre, Maureen, Swanson, Michael D., Gupta, Auroni, Claes, Sandra, Meagher, Jennifer L., Boonen, Arnaud, Zhang, Lihong, Kalveram, Birte, Raglow, Zoe, Freiberg, Alexander N., Prichard, Mark, Stuckey, Jeanne A., Schols, Dominique, Markovitz, David M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804308/
https://ncbi.nlm.nih.gov/pubmed/33436903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80577-7
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