Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity

Lectins, carbohydrate-binding proteins, have been regarded as potential antiviral agents, as some can bind glycans on viral surface glycoproteins and inactivate their functions. However, clinical development of lectins has been stalled by the mitogenicity of many of these proteins, which is the abil...

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Publicado no:Sci Rep
Main Authors: Covés-Datson, Evelyn M., King, Steven R., Legendre, Maureen, Swanson, Michael D., Gupta, Auroni, Claes, Sandra, Meagher, Jennifer L., Boonen, Arnaud, Zhang, Lihong, Kalveram, Birte, Raglow, Zoe, Freiberg, Alexander N., Prichard, Mark, Stuckey, Jeanne A., Schols, Dominique, Markovitz, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804308/
https://ncbi.nlm.nih.gov/pubmed/33436903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80577-7
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