Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity

Lectins, carbohydrate-binding proteins, have been regarded as potential antiviral agents, as some can bind glycans on viral surface glycoproteins and inactivate their functions. However, clinical development of lectins has been stalled by the mitogenicity of many of these proteins, which is the abil...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Covés-Datson, Evelyn M., King, Steven R., Legendre, Maureen, Swanson, Michael D., Gupta, Auroni, Claes, Sandra, Meagher, Jennifer L., Boonen, Arnaud, Zhang, Lihong, Kalveram, Birte, Raglow, Zoe, Freiberg, Alexander N., Prichard, Mark, Stuckey, Jeanne A., Schols, Dominique, Markovitz, David M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2021
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804308/
https://ncbi.nlm.nih.gov/pubmed/33436903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80577-7
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