Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines

The inhibition of Plasmodium cytosolic phenylalanine tRNA-synthetase (cFRS) by a novel series of bicyclic azetidines has shown the potential to prevent malaria transmission, provide prophylaxis, and offer single-dose cure in animal models of malaria. To date, however, the molecular basis of Plasmodi...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Nat Commun
Main Authors: Sharma, Manmohan, Malhotra, Nipun, Yogavel, Manickam, Harlos, Karl, Melillo, Bruno, Comer, Eamon, Gonse, Arthur, Parvez, Suhel, Mitasev, Branko, Fang, Francis G., Schreiber, Stuart L., Sharma, Amit
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7803973/
https://ncbi.nlm.nih.gov/pubmed/33436639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20478-5
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares