Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines

The inhibition of Plasmodium cytosolic phenylalanine tRNA-synthetase (cFRS) by a novel series of bicyclic azetidines has shown the potential to prevent malaria transmission, provide prophylaxis, and offer single-dose cure in animal models of malaria. To date, however, the molecular basis of Plasmodi...

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Udgivet i:Nat Commun
Main Authors: Sharma, Manmohan, Malhotra, Nipun, Yogavel, Manickam, Harlos, Karl, Melillo, Bruno, Comer, Eamon, Gonse, Arthur, Parvez, Suhel, Mitasev, Branko, Fang, Francis G., Schreiber, Stuart L., Sharma, Amit
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7803973/
https://ncbi.nlm.nih.gov/pubmed/33436639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20478-5
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