Base-modified aptamers obtained by cell-internalization SELEX facilitate cellular uptake of an antisense oligonucleotide

Intracellular delivery of oligonucleotides is important for their use as therapeutic drugs. The conjugation of molecules interacting with cell membrane proteins to enhance their internalization into cells is an effective strategy for delivering oligonucleotides. In the present study, we focused on c...

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Dettagli Bibliografici
Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Tanaka, Keisuke, Okuda, Takumi, Kasahara, Yuuya, Obika, Satoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7803630/
https://ncbi.nlm.nih.gov/pubmed/33473329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.11.016
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