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Base-modified aptamers obtained by cell-internalization SELEX facilitate cellular uptake of an antisense oligonucleotide

Intracellular delivery of oligonucleotides is important for their use as therapeutic drugs. The conjugation of molecules interacting with cell membrane proteins to enhance their internalization into cells is an effective strategy for delivering oligonucleotides. In the present study, we focused on c...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Mol Ther Nucleic Acids
Κύριοι συγγραφείς: Tanaka, Keisuke, Okuda, Takumi, Kasahara, Yuuya, Obika, Satoshi
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society of Gene & Cell Therapy 2020
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7803630/
https://ncbi.nlm.nih.gov/pubmed/33473329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.11.016
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