Shared and divergent phase separation and aggregation properties of brain-expressed ubiquilins

The brain-expressed ubiquilins, UBQLNs 1, 2 and 4, are highly homologous proteins that participate in multiple aspects of protein homeostasis and are implicated in neurodegenerative diseases. Studies have established that UBQLN2 forms liquid-like condensates and accumulates in pathogenic aggregates,...

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Vydáno v:Sci Rep
Hlavní autoři: Gerson, Julia E., Linton, Hunter, Xing, Jiazheng, Sutter, Alexandra B., Kakos, Fayth S., Ryou, Jaimie, Liggans, Nyjerus, Sharkey, Lisa M., Safren, Nathaniel, Paulson, Henry L., Ivanova, Magdalena I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801659/
https://ncbi.nlm.nih.gov/pubmed/33431932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78775-4
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