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Stabilizing the closed SARS-CoV-2 spike trimer
The trimeric spike (S) protein of SARS-CoV-2 is the primary focus of most vaccine design and development efforts. Due to intrinsic instability typical of class I fusion proteins, S tends to prematurely refold to the post-fusion conformation, compromising immunogenic properties and prefusion trimer y...
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| Gepubliceerd in: | Nat Commun |
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| Hoofdauteurs: | , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group UK
2021
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7801441/ https://ncbi.nlm.nih.gov/pubmed/33431842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20321-x |
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