A thermostable, closed SARS-CoV-2 spike protein trimer.

The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant target of the immune system. S exhibits substantial conformational flexibility. It transitions from closed to open conformations to expose its receptor-binding site, and subsequently from prefusion to po...

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Publicado no:Nat Struct Mol Biol
Main Authors: Xiong, Xiaoli, Qu, Kun, Ciazynska, Katarzyna A., Hosmillo, Myra, Carter, Andrew P., Ebrahimi, Soraya, Ke, Zunlong, Scheres, Sjors H.W., Bergamaschi, Laura, Grice, Guinevere L., Zhang, Ying, Nathan, James A., Baker, Stephen, James, Leo C., Baxendale, Helen E., Goodfellow, Ian, Doffinger, Rainer, Briggs, John A.G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116388/
https://ncbi.nlm.nih.gov/pubmed/32737467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0478-5
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