Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis

The approval of bedaquiline has placed energy metabolism in the limelight as an attractive target space for tuberculosis antibiotic development. While bedaquiline inhibits the mycobacterial F(1)F(0) ATP synthase, small molecules targeting other components of the oxidative phosphorylation pathway hav...

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Опубликовано в: :EMBO Mol Med
Главные авторы: Lee, Bei Shi, Hards, Kiel, Engelhart, Curtis A, Hasenoehrl, Erik J, Kalia, Nitin P, Mackenzie, Jared S, Sviriaeva, Ekaterina, Chong, Shi Min Sherilyn, Manimekalai, Malathy Sony S, Koh, Vanessa H, Chan, John, Xu, Jiayong, Alonso, Sylvie, Miller, Marvin J, Steyn, Adrie J C, Grüber, Gerhard, Schnappinger, Dirk, Berney, Michael, Cook, Gregory M, Moraski, Garrett C, Pethe, Kevin
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2020
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7799364/
https://ncbi.nlm.nih.gov/pubmed/33283973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202013207
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