Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection

The recent discovery of small molecules targeting the cytochrome bc(1):aa(3) in Mycobacterium tuberculosis triggered interest in the terminal respiratory oxidases for antituberculosis drug development. The mycobacterial cytochrome bc(1):aa(3) consists of a menaquinone:cytochrome c reductase (bc(1))...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kalia, Nitin P., Hasenoehrl, Erik J., Ab Rahman, Nurlilah B., Koh, Vanessa H., Ang, Michelle L. T., Sajorda, Dannah R., Hards, Kiel, Grüber, Gerhard, Alonso, Sylvie, Cook, Gregory M., Berney, Michael, Pethe, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514758/
https://ncbi.nlm.nih.gov/pubmed/28652330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706139114
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