Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection

The recent discovery of small molecules targeting the cytochrome bc(1):aa(3) in Mycobacterium tuberculosis triggered interest in the terminal respiratory oxidases for antituberculosis drug development. The mycobacterial cytochrome bc(1):aa(3) consists of a menaquinone:cytochrome c reductase (bc(1))...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kalia, Nitin P., Hasenoehrl, Erik J., Ab Rahman, Nurlilah B., Koh, Vanessa H., Ang, Michelle L. T., Sajorda, Dannah R., Hards, Kiel, Grüber, Gerhard, Alonso, Sylvie, Cook, Gregory M., Berney, Michael, Pethe, Kevin
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514758/
https://ncbi.nlm.nih.gov/pubmed/28652330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706139114
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