Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons

Solid tumors often grow in a micro-environment characterized by < 2% O(2) tension. This condition, together with the aberrant activation of specific oncogenic patwhays, increases the amount and activity of the hypoxia-inducible factor-1α (HIF-1α), a transcription factor that controls up to 200 ge...

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Bibliografske podrobnosti
izdano v:J Exp Clin Cancer Res
Main Authors: Akman, Muhlis, Belisario, Dimas Carolina, Salaroglio, Iris Chiara, Kopecka, Joanna, Donadelli, Massimo, De Smaele, Enrico, Riganti, Chiara
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7798239/
https://ncbi.nlm.nih.gov/pubmed/33423689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01824-3
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