P-glycoprotein-mediated chemoresistance is reversed by carbonic anhydrase XII inhibitors

Carbonic anhydrase XII (CAXII) is a membrane enzyme that maintains pH homeostasis and sustains optimum P-glycoprotein (Pgp) efflux activity in cancer cells. Here, we investigated a panel of eight CAXII inhibitors (compounds 1–8), for their potential to reverse Pgp mediated tumor cell chemoresistance...

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Kopecka, Joanna, Rankin, Gregory M., Salaroglio, Iris C., Poulsen, Sally-Ann, Riganti, Chiara
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349880/
https://ncbi.nlm.nih.gov/pubmed/27811376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13040
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