Saccharin: a Lead Compound for Structure-Based Drug Design of Carbonic Anhydrase IX Inhibitors

Carbonic anhydrase IX (CA IX) is a key modulator of aggressive tumor behavior and a prognostic marker and target for several cancers. Saccharin (SAC) based compounds may provide an avenue to overcome CA isoform specificity, as they display both nanomolar affinity and preferential binding, for CA IX...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Mahon, Brian P., Hendon, Alex M., Driscoll, Jenna M., Rankin, Gregory M., Poulsen, Sally-Ann, Supuran, Claudiu T., McKenna, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352949/
https://ncbi.nlm.nih.gov/pubmed/25614109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.12.030
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