Saccharin: a Lead Compound for Structure-Based Drug Design of Carbonic Anhydrase IX Inhibitors

Carbonic anhydrase IX (CA IX) is a key modulator of aggressive tumor behavior and a prognostic marker and target for several cancers. Saccharin (SAC) based compounds may provide an avenue to overcome CA isoform specificity, as they display both nanomolar affinity and preferential binding, for CA IX...

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Détails bibliographiques
Publié dans:Bioorg Med Chem
Auteurs principaux: Mahon, Brian P., Hendon, Alex M., Driscoll, Jenna M., Rankin, Gregory M., Poulsen, Sally-Ann, Supuran, Claudiu T., McKenna, Robert
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352949/
https://ncbi.nlm.nih.gov/pubmed/25614109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.12.030
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