Saccharin: a Lead Compound for Structure-Based Drug Design of Carbonic Anhydrase IX Inhibitors

Carbonic anhydrase IX (CA IX) is a key modulator of aggressive tumor behavior and a prognostic marker and target for several cancers. Saccharin (SAC) based compounds may provide an avenue to overcome CA isoform specificity, as they display both nanomolar affinity and preferential binding, for CA IX...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Mahon, Brian P., Hendon, Alex M., Driscoll, Jenna M., Rankin, Gregory M., Poulsen, Sally-Ann, Supuran, Claudiu T., McKenna, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352949/
https://ncbi.nlm.nih.gov/pubmed/25614109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.12.030
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