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Inhibition of carbonic anhydrase IX as a novel anticancer mechanism
Carbonic anhydrases (CA, EC 4.2.1.1) catalyze the interconversion bewteen carbon dioxide and bicarbonate with generation of protons. The carbonic anhydrase isozyme IX (CA IX) is highly overexpresed in hypoxic tumors and shows very restricted expression in normal tissues. CA IX is a dimeric protein p...
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Baishideng Publishing Group Co., Limited
2012
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3394083/ https://ncbi.nlm.nih.gov/pubmed/22787577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5306/wjco.v3.i7.98 |
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