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Carbonic Anhydrase Inhibition and the Management of Hypoxic Tumors

Hypoxia and acidosis are salient features of many tumors, leading to a completely different metabolism compared to normal cells. Two of the simplest metabolic products, protons and bicarbonate, are generated by the catalytic activity of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), with at...

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Detalhes bibliográficos
Publicado no:Metabolites
Autor principal: Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618333/
https://ncbi.nlm.nih.gov/pubmed/28926956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo7030048
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