Saccharin: a Lead Compound for Structure-Based Drug Design of Carbonic Anhydrase IX Inhibitors

Carbonic anhydrase IX (CA IX) is a key modulator of aggressive tumor behavior and a prognostic marker and target for several cancers. Saccharin (SAC) based compounds may provide an avenue to overcome CA isoform specificity, as they display both nanomolar affinity and preferential binding, for CA IX...

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Gepubliceerd in:Bioorg Med Chem
Hoofdauteurs: Mahon, Brian P., Hendon, Alex M., Driscoll, Jenna M., Rankin, Gregory M., Poulsen, Sally-Ann, Supuran, Claudiu T., McKenna, Robert
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352949/
https://ncbi.nlm.nih.gov/pubmed/25614109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.12.030
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