A class of carbonic anhydrase IX/XII – selective carboxylate inhibitors

A small series of 2,4-dioxothiazolidinyl acetic acids was prepared from thiourea, chloroacetic acid, aromatic aldehydes, and ethyl-2-bromoacetate. They were assayed for the inhibition of four physiologically relevant carbonic anhydrase (CA, EC 4.2.1.1) isoforms of human (h) origin, the cytosolic hCA...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Alhameed, Rakia Abd, Berrino, Emanuela, Almarhoon, Zainab, El-Faham, Ayman, Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7006686/
https://ncbi.nlm.nih.gov/pubmed/31967484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1715388
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