PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy

BACKGROUND: Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic reticulum (ER) stress, which activates the so-called unfolded protein response (UPR). Extensive and acute ER stress directs the UPR towards activation of death-triggering pathways. Cancer cells are selected t...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Salaroglio, Iris C., Panada, Elisa, Moiso, Enrico, Buondonno, Ilaria, Provero, Paolo, Rubinstein, Menachem, Kopecka, Joanna, Riganti, Chiara
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427528/
https://ncbi.nlm.nih.gov/pubmed/28499449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-017-0657-0
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