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PERK-Opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration
The unfolded protein response (UPR) plays a vital role in maintaining cell homeostasis as a consequence of endoplasmic reticulum (ER) stress. However, prolonged UPR activity leads to cell death. This time-dependent dual functionality of the UPR represents the adaptive and cytotoxic pathways that res...
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| Publicado no: | Curr Alzheimer Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6542591/ https://ncbi.nlm.nih.gov/pubmed/26679859 |
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