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PERK-Opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration

The unfolded protein response (UPR) plays a vital role in maintaining cell homeostasis as a consequence of endoplasmic reticulum (ER) stress. However, prolonged UPR activity leads to cell death. This time-dependent dual functionality of the UPR represents the adaptive and cytotoxic pathways that res...

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Bibliografiske detaljer
Udgivet i:Curr Alzheimer Res
Main Authors: Bell, Michelle C., Meier, Shelby E., Ingram, Alexandria L., Abisambra, Jose F.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542591/
https://ncbi.nlm.nih.gov/pubmed/26679859
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