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Misfolded proteins, endoplasmic reticulum stress and neurodegeneration
The accumulation of misfolded proteins (e.g. mutant or damaged proteins) triggers cellular stress responses that protect cells against the toxic buildup of such proteins. However, prolonged stress due to the buildup of these toxic proteins induces specific death pathways. Dissecting these pathways s...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3970707/ https://ncbi.nlm.nih.gov/pubmed/15530777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceb.2004.09.012 |
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