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The Cellular Response to Protein Misfolding in the Endoplasmic Reticulum

In eukaryotic cells, accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER) leads to a stress response. Cells respond to ER stress by upregulating the synthesis of ER resident protein chaperones, thus increasing the folding capacity in this organelle. In addition, this resp...

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Bibliografische gegevens
Gepubliceerd in:Gene Expr
Hoofdauteurs: Welihinda, Ajith A., Tirasophon, Witoon, Kaufman, Randal J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cognizant Communication Corporation 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6174664/
https://ncbi.nlm.nih.gov/pubmed/10440230
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