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The Cellular Response to Protein Misfolding in the Endoplasmic Reticulum

In eukaryotic cells, accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER) leads to a stress response. Cells respond to ER stress by upregulating the synthesis of ER resident protein chaperones, thus increasing the folding capacity in this organelle. In addition, this resp...

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Detalhes bibliográficos
Publicado no:Gene Expr
Main Authors: Welihinda, Ajith A., Tirasophon, Witoon, Kaufman, Randal J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cognizant Communication Corporation 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6174664/
https://ncbi.nlm.nih.gov/pubmed/10440230
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