Increased O-GlcNAcylation of Drp1 by amyloid-beta promotes mitochondrial fission and dysfunction in neuronal cells

As a dynamic organelle, mitochondria continuously fuse and divide with adjacent mitochondria. Imbalance in mitochondria dynamics leads to their dysfunction, which implicated in neurodegenerative diseases. However, how mitochondria alteration and glucose defect contribute to pathogenesis of Alzheimer...

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Bibliografiske detaljer
Udgivet i:Mol Brain
Main Authors: Park, So Jung, Bae, Ji-Eun, Jo, Doo Sin, Kim, Joon Bum, Park, Na Yeon, Fang, Jianguo, Jung, Yong-Keun, Jo, Dong Gyu, Cho, Dong-Hyung
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Micro Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797154/
https://ncbi.nlm.nih.gov/pubmed/33422108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-020-00727-w
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