Increased O-GlcNAcylation of Drp1 by amyloid-beta promotes mitochondrial fission and dysfunction in neuronal cells

As a dynamic organelle, mitochondria continuously fuse and divide with adjacent mitochondria. Imbalance in mitochondria dynamics leads to their dysfunction, which implicated in neurodegenerative diseases. However, how mitochondria alteration and glucose defect contribute to pathogenesis of Alzheimer...

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Vydáno v:Mol Brain
Hlavní autoři: Park, So Jung, Bae, Ji-Eun, Jo, Doo Sin, Kim, Joon Bum, Park, Na Yeon, Fang, Jianguo, Jung, Yong-Keun, Jo, Dong Gyu, Cho, Dong-Hyung
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Micro Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797154/
https://ncbi.nlm.nih.gov/pubmed/33422108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-020-00727-w
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