Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site

Coenzyme A (CoA) is a fundamental co-factor for all life, involved in numerous metabolic pathways and cellular processes, and its biosynthetic pathway has raised substantial interest as a drug target against multiple pathogens including Mycobacterium tuberculosis. The biosynthesis of CoA is performe...

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Publicado no:Nat Commun
Main Authors: Mendes, Vitor, Green, Simon R., Evans, Joanna C., Hess, Jeannine, Blaszczyk, Michal, Spry, Christina, Bryant, Owain, Cory-Wright, James, Chan, Daniel S-H., Torres, Pedro H. M., Wang, Zhe, Nahiyaan, Navid, O’Neill, Sandra, Damerow, Sebastian, Post, John, Bayliss, Tracy, Lynch, Sasha L., Coyne, Anthony G., Ray, Peter C., Abell, Chris, Rhee, Kyu Y., Boshoff, Helena I. M., Barry, Clifton E., Mizrahi, Valerie, Wyatt, Paul G., Blundell, Tom L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794376/
https://ncbi.nlm.nih.gov/pubmed/33420031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20224-x
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