Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity

[Image: see text] Coenzyme A (CoA) is a ubiquitous cofactor present in all living cells and estimated to be required for up to 9% of intracellular enzymatic reactions. Mycobacterium tuberculosis (Mtb) relies on its own ability to biosynthesize CoA to meet the needs of the myriad enzymatic reactions...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Evans, Joanna C., Murugesan, Dinakaran, Post, John M., Mendes, Vitor, Wang, Zhe, Nahiyaan, Navid, Lynch, Sasha L., Thompson, Stephen, Green, Simon R., Ray, Peter C., Hess, Jeannine, Spry, Christina, Coyne, Anthony G., Abell, Chris, Boshoff, Helena I. M., Wyatt, Paul G., Rhee, Kyu Y., Blundell, Tom L., Barry, Clifton E., Mizrahi, Valerie
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205227/
https://ncbi.nlm.nih.gov/pubmed/33939919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00904
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