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SAR and identification of 2-(quinolin-4-yloxy)acetamides as Mycobacterium tuberculosis cytochrome bc (1) inhibitors

A previous phenotypic screen by GSK identified 2-(quinolin-4-yloxy)acetamides as potent growth inhibitors of Mycobacterium tuberculosis (Mtb). We report the results of a preliminary structure–activity relationship (SAR) study of the compound class which has yielded more potent inhibitors. An Mtb cyt...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Phummarin, Narisa, Boshoff, Helena I., Tsang, Patricia S., Dalton, James, Wiles, Siouxsie, Barry 3rd, Clifton E., Copp, Brent R.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5292992/
https://ncbi.nlm.nih.gov/pubmed/28337336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00236f
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