Effects of blocking mGluR5 on primate dorsolateral prefrontal cortical neuronal firing and working memory performance

RATIONALE: Metabotropic glutamate type 5 receptor (mGluR5) antagonists are under development for treating cognitive disorders such as Fragile X syndrome and Alzheimer’s disease, largely based on success in mouse models, where post-synaptic mGluR5 stimulation weakens synaptic functions in hippocampus...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Psychopharmacology (Berl)
Main Authors: Yang, Sheng-Tao, Wang, Min, Galvin, Veronica, Yang, Yang, Arnsten, Amy F. T.
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2020
Teme:
Original Investigation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794104/
https://ncbi.nlm.nih.gov/pubmed/32939596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-020-05661-2
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