A Novel Dopamine D1 Receptor Agonist Excites Delay-Dependent Working Memory-Related Neuronal Firing in Primate Dorsolateral Prefrontal Cortex

Decades of research have emphasized the importance of dopamine (DA) D1 receptor (D1R) mechanisms to dorsolateral prefrontal cortex (dlPFC) working memory function, and the hope that D1R agonists could be used to treat cognitive disorders. However, existing D1R agonists all have had high affinity for...

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Veröffentlicht in:Neuropharmacology
Hauptverfasser: Wang, Min, Datta, Dibyadeep, Enwright, John, Galvin, Veronica, Yang, Sheng-Tao, Paspalas, Constantinos, Kozak, Rouba, Gray, David L., Lewis, David A., Arnsten, Amy F.T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475613/
https://ncbi.nlm.nih.gov/pubmed/30858103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2019.03.001
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