Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits

cAMP signaling has powerful, negative effects on cognitive functions of the primate dorsolateral prefrontal cortex (dlPFC), opening potassium channels to reduce firing and impair working memory, and increasing tau phosphorylation in aging neurons. This contrasts with cAMP actions in classic circuits...

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Détails bibliographiques
Publié dans:Front Neuroanat
Auteurs principaux: Datta, Dibyadeep, Enwright, John F., Arion, Dominique, Paspalas, Constantinos D., Morozov, Yury M., Lewis, David A., Arnsten, Amy F. T.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Neuroanatomy
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714912/
https://ncbi.nlm.nih.gov/pubmed/33328902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnana.2020.578483
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