Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits

cAMP signaling has powerful, negative effects on cognitive functions of the primate dorsolateral prefrontal cortex (dlPFC), opening potassium channels to reduce firing and impair working memory, and increasing tau phosphorylation in aging neurons. This contrasts with cAMP actions in classic circuits...

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Detalhes bibliográficos
Publicado no:Front Neuroanat
Main Authors: Datta, Dibyadeep, Enwright, John F., Arion, Dominique, Paspalas, Constantinos D., Morozov, Yury M., Lewis, David A., Arnsten, Amy F. T.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroanatomy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714912/
https://ncbi.nlm.nih.gov/pubmed/33328902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnana.2020.578483
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