Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits

cAMP signaling has powerful, negative effects on cognitive functions of the primate dorsolateral prefrontal cortex (dlPFC), opening potassium channels to reduce firing and impair working memory, and increasing tau phosphorylation in aging neurons. This contrasts with cAMP actions in classic circuits...

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發表在:Front Neuroanat
Main Authors: Datta, Dibyadeep, Enwright, John F., Arion, Dominique, Paspalas, Constantinos D., Morozov, Yury M., Lewis, David A., Arnsten, Amy F. T.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2020
主題:
Neuroanatomy
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714912/
https://ncbi.nlm.nih.gov/pubmed/33328902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnana.2020.578483
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