Global Genome Demethylation Causes Transcription-Associated DNA Double Strand Breaks in HPV-Associated Head and Neck Cancer Cells

SIMPLE SUMMARY: High levels of global genome methylation in HPV-associated head and neck cancer prompted us to explore demethylation as a potential treatment by determining mechanisms of its toxicity in HPV-positive head and neck cancer cells. Previously, we reported that demethylating drug 5-azaC s...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Hajek, Michael, Biktasova, Asel, Sewell, Andrew, Gary, Cyril, Cantalupo, Paul, Anderson, Karen S., Yarbrough, Wendell G., Issaeva, Natalia
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793113/
https://ncbi.nlm.nih.gov/pubmed/33374558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13010021
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