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Pharmacological Inhibition of mTORC2 Reduces Migration and Metastasis in Melanoma

Despite recent advances in therapy, liver metastasis from melanoma is still associated with poor prognosis. Although targeting the mTOR signaling pathway exerts potent anti-tumor activity, little is known about specific mTORC2 inhibition regarding liver metastasis. Using the novel mTORC2 specific in...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Guenzle, Jessica, Akasaka, Harue, Joechle, Katharina, Reichardt, Wilfried, Venkatasamy, Aina, Hoeppner, Jens, Hellerbrand, Claus, Fichtner-Feigl, Stefan, Lang, Sven A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792954/
https://ncbi.nlm.nih.gov/pubmed/33375117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010030
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