Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis()()

Mammalian target of rapamycin complex 2 (mTORC2) with its pivotal component rapamycin-insensitive companion of mTOR (RICTOR) is the major regulator of AKT phosphorylation and is increasingly implicated in tumor growth and progression. In cutaneous melanoma, an extremely aggressive and highly metasta...

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Détails bibliographiques
Publié dans:Neoplasia
Auteurs principaux: Schmidt, Katharina M., Dietrich, Peter, Hackl, Christina, Guenzle, Jessica, Bronsert, Peter, Wagner, Christine, Fichtner-Feigl, Stefan, Schlitt, Hans J., Geissler, Edward K., Hellerbrand, Claus, Lang, Sven A.
Format: Artigo
Langue:Inglês
Publié: Neoplasia Press 2018
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Original article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224335/
https://ncbi.nlm.nih.gov/pubmed/30404068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2018.10.001
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