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Humanized mouse models of Cooley’s anemia: correct fetal-to-adult hemoglobin switching, disease onset, and disease pathology
β thalassemia major or Cooley’s Anemia (CA) has been difficult to model in mice due to their lack of a fetal hemoglobin gene equivalent. This summary describes novel preclinical humanized mouse models of CA that survive on human fetal hemoglobin at birth and are blood-transfusion dependent for life...
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| Veröffentlicht in: | Ann N Y Acad Sci |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7791968/ https://ncbi.nlm.nih.gov/pubmed/20712771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1749-6632.2010.05547.x |
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