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Human Globin Knock-in Mice Complete Fetal-to-Adult Hemoglobin Switching in Postnatal Development
Elevated levels of fetal γ-globin can cure disorders caused by mutations in the adult β-globin gene. This clinical finding has motivated studies to improve our understanding of hemoglobin switching. Unlike humans, mice do not express a distinct fetal globin. Transgenic mice that contain the human β-...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3028651/ https://ncbi.nlm.nih.gov/pubmed/21173165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00725-10 |
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