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Human Globin Knock-in Mice Complete Fetal-to-Adult Hemoglobin Switching in Postnatal Development

Elevated levels of fetal γ-globin can cure disorders caused by mutations in the adult β-globin gene. This clinical finding has motivated studies to improve our understanding of hemoglobin switching. Unlike humans, mice do not express a distinct fetal globin. Transgenic mice that contain the human β-...

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Bibliografiske detaljer
Main Authors: McConnell, Sean C., Huo, Yongliang, Liu, Shanrun, Ryan, Thomas M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028651/
https://ncbi.nlm.nih.gov/pubmed/21173165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00725-10
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