enAsCas12a Enables CRISPR-Directed Evolution to Screen for Functional Drug Resistance Mutations in Sequences Inaccessible to SpCas9

While drug resistance mutations provide the gold standard proof for drug target engagement, target deconvolution of inhibitors identified from a phenotypic screen remains challenging. Genetic screening for functional in-frame drug resistance mutations by tiling CRISPR-Cas nucleases across protein co...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Neggers, Jasper Edgar, Jacquemyn, Maarten, Dierckx, Tim, Kleinstiver, Benjamin Peter, Thibaut, Hendrik Jan, Daelemans, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7791016/
https://ncbi.nlm.nih.gov/pubmed/33002419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.09.025
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