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Deletion of transcription factor binding motifs using the CRISPR/spCas9 system in the β-globin LCR

Transcription factors play roles in gene transcription through direct binding to their motifs in genome, and inhibiting this binding provides an effective strategy for studying their roles. Here, we applied the CRISPR (clustered, regularly interspaced, short palindromic repeat)/spCas9 (CRISPR-associ...

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Detalles Bibliográficos
Publicado en:Biosci Rep
Main Authors: Kim, Yea Woon, Kim, AeRi
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2017
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634328/
https://ncbi.nlm.nih.gov/pubmed/28729249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20170976
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