The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription

TAL1 is a key hematopoietic transcription factor that binds to regulatory regions of a large cohort of erythroid genes as part of a complex with GATA-1, LMO2 and Ldb1. The complex mediates long-range interaction between the β-globin locus control region (LCR) and active globin genes, and although TA...

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Bibliographic Details
Main Authors: Yun, Won Ju, Kim, Yea Woon, Kang, Yujin, Lee, Jungbae, Dean, Ann, Kim, AeRi
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985645/
https://ncbi.nlm.nih.gov/pubmed/24470145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku072
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