Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody Drug Conjugates to Increase In Vivo Efficacy

Several antibody-drug conjugates (ADCs) showing strong clinical responses in solid tumors target high expression antigens (HER2, TROP2, Nectin-4, and folate receptor alpha/FRα). Highly expressed tumor antigens often have significant low-level expression in normal tissues, resulting in the potential...

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I publikationen:Mol Cancer Ther
Huvudupphovsmän: Ponte, Jose F., Lanieri, Leanne, Khera, Eshita, Laleau, Rassol, Ab, Olga, Espelin, Christopher, Kohli, Neeraj, Matin, Bahar, Setiady, Yulius, Miller, Michael L., Keating, Thomas A., Chari, Ravi, Pinkas, Jan, Gregory, Richard, Thurber, Greg M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790875/
https://ncbi.nlm.nih.gov/pubmed/33177153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0451
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