Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates

[Image: see text] Antibody–drug conjugates (ADCs) that incorporate the exatecan derivative DXd in their payload are showing promising clinical results in solid tumor indications. The payload has an F-ring that also contains a second chiral center, both of which complicate its synthesis and derivatiz...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Li, Wei, Veale, Karen H., Qiu, Qifeng, Sinkevicius, Kerstin W., Maloney, Erin K., Costoplus, Juliet A., Lau, Janet, Evans, Helen L., Setiady, Yulius, Ab, Olga, Abbott, Stephen M., Lee, Jenny, Wisitpitthaya, Somsinee, Skaletskaya, Anna, Wang, Lintao, Keating, Thomas A., Chari, Ravi V. J., Widdison, Wayne C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792168/
https://ncbi.nlm.nih.gov/pubmed/31620223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00301
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