Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates

[Image: see text] Antibody–drug conjugates (ADCs) that incorporate the exatecan derivative DXd in their payload are showing promising clinical results in solid tumor indications. The payload has an F-ring that also contains a second chiral center, both of which complicate its synthesis and derivatiz...

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Udgivet i:ACS Med Chem Lett
Main Authors: Li, Wei, Veale, Karen H., Qiu, Qifeng, Sinkevicius, Kerstin W., Maloney, Erin K., Costoplus, Juliet A., Lau, Janet, Evans, Helen L., Setiady, Yulius, Ab, Olga, Abbott, Stephen M., Lee, Jenny, Wisitpitthaya, Somsinee, Skaletskaya, Anna, Wang, Lintao, Keating, Thomas A., Chari, Ravi V. J., Widdison, Wayne C.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792168/
https://ncbi.nlm.nih.gov/pubmed/31620223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00301
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