Synthesis of Highly Potent N-10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody–Drug Conjugates (ADCs)

[Image: see text] Indolinobenzodiazepine DNA alkylators (IGNs) are the cytotoxic payloads in antibody–drug conjugates (ADCs) currently undergoing Phase I clinical evaluation (IMGN779, IMGN632, and TAK164). These ADCs possess linkers that have been incorporated into a central substituted phenyl space...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:ACS Med Chem Lett
Autores principales: Archer, Katie E., Reid, Emily E., Shizuka, Manami, Woods, James, Harris, Luke, Maloney, Erin K., Bartle, Laura M., Ab, Olga, Wilhelm, Alan, Setiady, Yulius, Ponte, Jose F., Singh, Rajeeva, Keating, Thomas A., Chari, Ravi V. J., Miller, Michael L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2019
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691681/
https://ncbi.nlm.nih.gov/pubmed/31413807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00254
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares